Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes
نویسندگان
چکیده
منابع مشابه
Palladium-catalyzed carbonylative Sonogashira coupling between aryl triazenes and alkynes.
We developed a palladium-catalyzed carbonylative Sonogashira reaction with aryl triazenes and alkynes as substrates and methanesulfonic acid as the additive. A series of α,β-ynones were synthesized by this alternative procedure. Notably, bromides, iodides and hydroxyl groups could be well-tolerated under these reaction conditions.
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An efficient Pd-catalyzed cross-coupling/cycloisomerization of 3-(2-pyridyl) propargyl carbonates with organoboronic acids has been developed, which provides a straightforward route for the synthesis of 1,3-disubstituted indolizines with a wide variety of substituents. The mechanistic study indicates that the reaction proceeds via formation of an allenyl pyridine intermediate through palladium-...
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Benzoxazinones represent a class of annulated nitrogen heterocycles that are of interest to organic synthesis owing to their various biological activities. Among the different methodologies developed for their preparation, cyclization of anthranilic acid, N-acylanthranilic acid, or isotonic anhydride are most accepted. Although alternative methodologies are known, the availability of substrates...
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A cationic palladium complex-catalyzed cross-coupling of alkynes with alkenes is presented, which occurs selectively under the hydrosilylation conditions using trichlorosilane. The unique reaction might be well understood in terms of an initial hydropalladation of a given 1-alkyne to form regioselectively a 1-alkenylpalladium species, which, in turn, undergoes easily and specifically an alkene ...
متن کاملPalladium‐Catalyzed Oxidative Synthesis of α‐Acetoxylated Enones from Alkynes
We report a palladium-catalyzed oxidative functionalization of alkynes to generate α-acetoxylated enones in one step. A range of functional groups are well-tolerated in this reaction. Mechanistic studies, including the use of (18) O-labeled DMSO, revealed that the ketone oxygen atom in the product originates from DMSO.
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2021
ISSN: 2041-6520,2041-6539
DOI: 10.1039/d0sc03977b